Plasmacrisis is a game mode in which a surplus amount of plasma has been delivered to the station. All the canisters are defective and are set to release within a randomized amount of time. The goal of the mode is to contain the plasma and any fires caused by its release. The station's AI must prevent anyone from leaving in this mode, and must also help the crew contain the plasma. Once a majority of the station has been destroyed, the station can be considered a lost cause and the players are allowed to evacuate. This is considered a draw. If the plasma is contained, the game can either continue as extended or the players can evacuate. Both are grounds for winning. If all players are killed in the process, the game is lost.

Note: This game mode mainly only available on Relic servers.